2. Neurological Disease

Neurological Disease

Neurological Disease

Related Products

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-101250R
    Glemanserin (Standard) 107703-78-6 98%
    Glemanserin (Standard) is the analytical standard of Glemanserin. This product is intended for research and analytical applications. Glemanserin (MDL11939) is a potent and selective antagonist for serotonin receptor 5-HT2A (Ki=2.89, 0.54 and 2.5 nM for rat 5-HT2A, rabbit 5-HT2A and human 5-HT2A, respectively).
    Glemanserin (Standard)
  • HY-101254R
    Luzindole (Standard) 117946-91-5 98%
    Luzindole (Standard) is the analytical standard of Luzindole. This product is intended for research and analytical applications. Luzindole (N-0774) is a selective melatonin receptor antagonist. Luzindole preferentially targets MT2 (Mel1b) over MT1 (Mel1a) with Ki values of 10.2 and 158 nM for human MT2 and MT1, respectively. Luzindole suppresses experimental autoimmune encephalomyelitis (EAE), and exerts antidepressant-like activity.
    Luzindole (Standard)
  • HY-101271R
    WAY-200070 (Standard) 440122-66-7 98%
    WAY-200070 (Standard) is the analytical standard of WAY-200070 (HY-101271). This product is intended for research and analytical applications. WAY-200070 is a selective estrogen receptor β (ERβ) agonist with an IC50 of 2.3 nM.
    WAY-200070 (Standard)
  • HY-101279R
    ST034307 (Standard) 133406-29-8 98%
    ST034307 (Standard) is the analytical standard of ST034307 (HY-101279). This product is intended for research and analytical applications. ST034307 is a potent and selective adenylyl cyclase 1 (AC1) inhibitor, with IC50 of 2.3 μM.
    ST034307 (Standard)
  • HY-101281R
    VU 6008667 (Standard) 2092923-21-0 98%
    VU 6008667 (Standard) is the analytical standard of VU 6008667 (HY-101281). This product is intended for research and analytical applications. VU 6008667 is a selective negative allosteric modulator of M5 NAM with IC50s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. High CNS penetration.
    VU 6008667 (Standard)
  • HY-101293R
    VU0359595 (Standard) 1246303-14-9 98%
    VU0359595 (Standard) is the analytical standard of VU0359595 (HY-101293). This product is intended for research and analytical applications. VU0359595 (CID-53361951; ML-270) is a potent and selective pharmacological phospholipase D1 (PLD1) inhibitor with an IC50 of 3.7 nM. VU0359595 is >1700-fold selective for PLD1 over PLD2 (IC50 of 6.4 μM). VU0359595 can be used for the research of cancer, diabetes, neurodegenerative and inflammatory diseases.
    VU0359595 (Standard)
  • HY-101298R
    Paprotrain (Standard) 57046-73-8 98%
    Paprotrain (Standard) is the analytical standard of Paprotrain (HY-101298). This product is intended for research and analytical applications. Paprotrain is a cell-permeable inhibitor of the kinesin MKLP-2, inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM and shows a moderate inhibition activity on DYRK1A with an IC50 of 5.5 μM.
    Paprotrain (Standard)
  • HY-101300R
    Cirazoline hydrochloride (Standard) 40600-13-3 98%
    Cirazoline (hydrochloride) (Standard) is the analytical standard of Cirazoline (hydrochloride). This product is intended for research and analytical applications. Cirazoline hydrochloride (LD 3098 hydrochloride) is a potent competitive full?α1A-adrenergic receptor (α1A-AR) agonist (Ki=120 nM) and only a partial agonist at α1B-AR (Ki= 960 nM) and α1D-AR (Ki=660 nM).
    Cirazoline hydrochloride (Standard)
  • HY-101301A
    RS 45041-190 hydrochloride 204274-74-8 98%
    RS 45041-190 hydrochloride is a high-affinity ligand for I2 imidazoline receptors, with the pKis of 8.66, 9.37, 9.32, and 8.85 in rat, rabbit, dog and baboon kidney, respectively. RS 45041-190 hydrochloride shows moderate potency for the inhibition of monoamine oxidase A in vitro (pIC50= 6.12), but had much lower potency for monoamine oxidase B (pIC50 = 4.47).
    RS 45041-190 hydrochloride
  • HY-101310R
    SYM 2081 (Standard) 31137-74-3 98%
    SYM 2081 (Standard) is the analytical standard of SYM 2081 (HY-101310). This product is intended for research and analytical applications. SYM 2081 is a kainate receptor agonist. SYM 2081 is a substrate of EAAT1 (Km of 54 μM). SYM 2081 inhibits EAAT2-mediated glutamate transport (Kb is 3.4 μM in Xenopus oocytes), modulates Apoptotic signaling pathways (increases Bcl-2 and decreases Bax/caspase-3 expression). SYM 2081 exhibits neuroprotective activity. SYM 2081 can be used in the study of hypoxic-ischemic brain damage and inflammatory or neuropathic pain.
    SYM 2081 (Standard)
  • HY-101313B
    (S)-Remoxipride hydrochloride hydrate 117591-79-4 98%
    (S)-Remoxipride ((-)-Remoxipride) hydrochloride hydrate ((S)-Remoxipride hydrochloride hydrate) is a selective dopamine D2-receptor antagonist with an IC50 value of 1.57 μM. (S)-Remoxipride hydrochloride hydrate can be used for the research of psychotic disorder.
    (S)-Remoxipride hydrochloride hydrate
  • HY-101315R
    AHN 1-055 hydrochloride (Standard) 202646-03-5 98%
    AHN 1-055 (hydrochloride) (Standard) is the analytical standard of AHN 1-055 (hydrochloride) (HY-101315). This product is intended for research and analytical applications. AHN 1-055 hydrochloride is a dopamine uptake inhibitor, with an IC50 of 71 nM. AHN 1-055 hydrochloride binds with high affinity to the dopamine transporter (DAT).
    AHN 1-055 hydrochloride (Standard)
  • HY-101323R
    Olvanil (Standard) 58493-49-5
    Olvanil (Standard) is the analytical standard of Olvanil. This product is intended for research and analytical applications. Olvanil (NE-19550) is an analgesic and an agonist of transient receptor potential vanilloid type 1 (TRPV1) channels with an EC50 of 0.7 nM.
    Olvanil (Standard)
  • HY-101331R
    Phenylbiguanide (Standard) 102-02-3
    Phenylbiguanide (Standard) is the analytical standard of Phenylbiguanide. This product is intended for research and analytical applications. Phenylbiguanide is a 5-HT3 receptor selective agonist with an EC50 of 3.0±0.1 μM.
    Phenylbiguanide (Standard)
  • HY-101334A
    MPDC hydrochloride 98%
    MPDC hydrochloride is a potent and competitive inhibitor of the Na+-dependent high-affinity glutamate transporter in forebrain synaptosomes.
    MPDC hydrochloride
  • HY-101341R
    RS 67333 hydrochloride (Standard) 168986-60-5 98%
    RS 67333 (hydrochloride) (Standard) is the analytical standard of RS 67333 (hydrochloride) (HY-101341). This product is intended for research and analytical applications. RS 67333 hydrochloride is a potent and selective 5-HT4 receptor (5-HT4R) partial agonist with a pKi of 8.7 in guinea-pig striatum. RS 67333 hydrochloride exhibits lower affinities at several other receptors including 5-HT1A, 5-HT1D, 5-HT2A, 5-HT2C, dopamine D1, D2 and muscarinic M1-M3 receptors. RS 67333 hydrochloride has neuroprotective effects, and can be used for Alzheimer's disease research.
    RS 67333 hydrochloride (Standard)
  • HY-101346R
    ZD7288 (Standard) 133059-99-1 98%
    ZD7288 (Standard) is the analytical standard of ZD7288 (HY-101346). This product is intended for research and analytical applications. ZD7288 (ICI D7288) is a selective hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker.
    ZD7288 (Standard)
  • HY-101348R
    L-741626 (Standard) 81226-60-0
    L-741626 (Standard) is the analytical standard of L-741626. This product is intended for research and analytical applications. L-741626 is a selective D2 dopamine receptor antagonist, with the Ki values of 2.4, 100 and 220 nM for human D2, D3 and D4 receptors respectively.
    L-741626 (Standard)
  • HY-101350R
    QX-314 bromide (Standard) 24003-58-5
    QX-314 (bromide) (Standard) is the analytical standard of QX-314 (bromide) (HY-101350). This product is intended for research and analytical applications. QX-314 bromide is a membrane-impermeable permanently charged sodium channel blocker.
    QX-314 bromide (Standard)
  • HY-101358R
    8-M-PDOT (Standard) 134865-70-6 98%
    8-M-PDOT (Standard) is the analytical standard of 8-M-PDOT (HY-101358). This product is intended for research and analytical applications. 8-M-PDOT (AH-002) is a selective melatonin MT2 receptor agonist. 8-M-PDOT is 5.2-fold selective for MT2 over MT1 receptors. 8-M-PDOT binds human recombinant MT2 and MT2 receptors with pKi values of 8.23 and 8.95 respectively. 8-M-PDOT has anxiolytic-like activity.
    8-M-PDOT (Standard)
Cat. No. Product Name / Synonyms Application Reactivity